Tu'uhevaha J Kaitu'u-Lino Selected Research

Endoglin

1/2020	Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia.
3/2019	Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction.
7/2018	Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia.
1/2018	Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.
12/2017	Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.
11/2017	Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta.
4/2016	Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.
3/2016	Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.
1/2016	Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta.
11/2015	Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion.

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Tu'uhevaha J Kaitu'u-Lino Research Topics

Disease

63	Pre-Eclampsia (Preeclampsia) 08/2023 - 01/2012
16	Hypoxia (Hypoxemia) 07/2023 - 01/2014
15	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2023 - 03/2013
9	Inflammation (Inflammations) 01/2024 - 12/2016
5	Birth Weight (Birth Weights) 12/2022 - 08/2018
4	Necrosis 03/2023 - 01/2019
4	Hypertension (High Blood Pressure) 01/2023 - 09/2015
3	Premature Birth (Birth, Premature) 01/2024 - 01/2023
3	Gestational Diabetes (Gestational Diabetes Mellitus) 09/2023 - 01/2019
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 01/2022
3	Ectopic Pregnancy 01/2019 - 02/2013
3	Spontaneous Abortion (Miscarriage) 01/2014 - 01/2012
2	Placental Insufficiency 01/2020 - 01/2020
2	Pregnancy Complications 01/2019 - 09/2015
2	Neoplasms (Cancer) 03/2018 - 02/2013
1	Sepsis (Septicemia) 01/2024
1	AIDS-Related Complex (ARC) 11/2022
1	Obesity 07/2022
1	Eclampsia 01/2022
1	Fetal Hypoxia 08/2021
1	Vascular Diseases (Vascular Disease) 01/2021

Drug/Important Bio-Agent (IBA)

24	Messenger RNA (mRNA)IBA 07/2023 - 03/2013
18	Proteins (Proteins, Gene)FDA Link 08/2023 - 01/2014
17	Biomarkers (Surrogate Marker)IBA 08/2023 - 01/2012
15	EndoglinIBA 01/2020 - 01/2012
11	Tyrosine (L-Tyrosine)FDA Link 08/2023 - 10/2014
10	Metformin (Glucophage)FDA LinkGeneric 12/2022 - 03/2016
9	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 03/2019 - 01/2016
7	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2023 - 08/2018
7	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2023 - 03/2019
7	Esomeprazole (Nexium)FDA Link 12/2022 - 01/2018
6	Proton Pump InhibitorsIBA 01/2023 - 12/2020
5	CytokinesIBA 07/2023 - 01/2014
5	AntioxidantsIBA 01/2022 - 01/2018
5	Pravastatin (Pravachol)FDA LinkGeneric 01/2022 - 09/2015
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023 - 01/2016
4	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 08/2022 - 07/2018
3	Endothelin-1 (Endothelin 1)IBA 09/2023 - 07/2018
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2022 - 03/2016
3	RNA (Ribonucleic Acid)IBA 01/2020 - 04/2016
3	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 07/2018 - 03/2016
2	EnzymesIBA 03/2023 - 10/2021
2	Atrial Natriuretic Factor (ANF)IBA 03/2023 - 05/2013
2	arginine methyl esterIBA 01/2023 - 08/2022
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 08/2022 - 07/2022
2	activin AIBA 03/2022 - 04/2009
2	Serine (L-Serine)FDA Link 01/2022 - 01/2020
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 01/2020
2	MelatoninIBA 12/2020 - 01/2018
2	ResveratrolIBA 12/2020 - 12/2017
2	Sildenafil Citrate (Viagra)FDA Link 12/2020 - 07/2018
2	Simvastatin (Zocor)FDA LinkGeneric 04/2020 - 01/2016
2	Rosuvastatin Calcium (Crestor)FDA Link 04/2020 - 01/2016
2	Epidermal Growth Factor (EGF)IBA 10/2018 - 01/2017
2	Peptides (Polypeptides)IBA 01/2017 - 07/2015
2	Angiogenic ProteinsIBA 03/2012 - 01/2012
2	Contraceptive Agents (Contraceptives)IBA 08/2008 - 01/2007
2	Progestins (Progestagens)IBA 08/2008 - 01/2007
1	TicagrelorIBA 01/2024
1	Insulin (Novolin)FDA Link 09/2023
1	Cholesterol Esters (Cholesteryl Esters)IBA 08/2023
1	Phosphatidylinositols (Phosphatidylinositol)IBA 08/2023
1	LipidsIBA 08/2023
1	Atrial Natriuretic Factor Receptors (Atrial Natriuretic Factor Receptor)IBA 03/2023
1	Tocolytic Agents (Tocolytics)IBA 01/2023
1	AntibodiesIBA 01/2023
1	MucinsIBA 01/2023
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2023
1	Calcium Channels (Calcium Channel)IBA 01/2023
1	Lanthanoid Series Elements (Lanthanides)IBA 01/2023
1	Nifedipine (Adalat)FDA LinkGeneric 01/2023
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2023
1	Matrix Metalloproteinases (MMPs)IBA 01/2023
1	Prostaglandin Antagonists (Prostaglandin Antagonist)IBA 01/2023
1	eosinylphosphatidylethanolamine (EOPE)IBA 01/2023
1	Endothelial Protein C ReceptorIBA 12/2022
1	Lansoprazole (Prevacid)FDA LinkGeneric 12/2022
1	Protein CIBA 12/2022
1	Rabeprazole (Aciphex)FDA Link 12/2022
1	CholesterolIBA 11/2022
1	HydrolasesIBA 08/2022
1	Vasoconstrictor AgentsIBA 08/2022
1	C-Reactive ProteinIBA 08/2022
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	Plant ExtractsIBA 01/2022
1	pregnancy-specific beta-1-glycoprotein 7IBA 01/2022
1	Galectin 3 (LGALS3)IBA 01/2022
1	MicronutrientsIBA 01/2022
1	Member 2 Group A Nuclear Receptor Subfamily 4IBA 10/2021
1	Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA 08/2021
1	Carvedilol (Coreg)FDA LinkGeneric 07/2021
1	Bisoprolol (Concor)FDA LinkGeneric 07/2021
1	Metoprolol (Toprol-XL)FDA LinkGeneric 07/2021
1	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2021
1	Syndecan-1 (Syndecan 1)IBA 01/2021
1	Growth Differentiation Factor 15IBA 01/2021
1	Trace Elements (Biometals)IBA 01/2021

Therapy/Procedure

12	Therapeutics 01/2024 - 03/2012
1	Length of Stay 01/2021